The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations

• Κύριοι συγγραφείς: J. Daniel Martínez (Συγγραφέας), Angela S. Infantino (Συγγραφέας), Pablo Valverde (Συγγραφέας), Tammo Diercks (Συγγραφέας), Sandra Delgado (Συγγραφέας), Niels-Christian Reichardt (Συγγραφέας), Ana Ardá (Συγγραφέας), Francisco Javier Cañada (Συγγραφέας), Stefan Oscarson (Συγγραφέας), Jesús Jiménez-Barbero (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2020-08-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Fluorinated glycomimetics are frequently employed to study and eventually modulate protein-glycan interactions. However, complex glycans and their glycomimetics may display multiple binding epitopes that enormously complicate the access to a complete picture of the protein-ligand complexes. We herei...