The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations

• Hoofdauteurs: J. Daniel Martínez (Auteur), Angela S. Infantino (Auteur), Pablo Valverde (Auteur), Tammo Diercks (Auteur), Sandra Delgado (Auteur), Niels-Christian Reichardt (Auteur), Ana Ardá (Auteur), Francisco Javier Cañada (Auteur), Stefan Oscarson (Auteur), Jesús Jiménez-Barbero (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2020-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Fluorinated glycomimetics are frequently employed to study and eventually modulate protein-glycan interactions. However, complex glycans and their glycomimetics may display multiple binding epitopes that enormously complicate the access to a complete picture of the protein-ligand complexes. We herei...