The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations

• Main Authors: J. Daniel Martínez (Author), Angela S. Infantino (Author), Pablo Valverde (Author), Tammo Diercks (Author), Sandra Delgado (Author), Niels-Christian Reichardt (Author), Ana Ardá (Author), Francisco Javier Cañada (Author), Stefan Oscarson (Author), Jesús Jiménez-Barbero (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fluorinated glycomimetics are frequently employed to study and eventually modulate protein-glycan interactions. However, complex glycans and their glycomimetics may display multiple binding epitopes that enormously complicate the access to a complete picture of the protein-ligand complexes. We herei...