Drug Repositioning for Noonan and LEOPARD Syndromes by Integrating Transcriptomics With a Structure-Based Approach

• Main Authors: Liyuan Zhu (Author), Ruth Roberts (Author), Ruili Huang (Author), Jinghua Zhao (Author), Menghang Xia (Author), Brian Delavan (Author), Mike Mikailov (Author), Weida Tong (Author), Zhichao Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Noonan and LEOPARD syndromes (NS and LS) belong to a group of related disorders called RASopathies characterized by abnormalities of multiple organs and systems including hypertrophic cardiomyopathy and dysmorphic facial features. There are no approved drugs for these two rare diseases, but it is kn...