Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5'-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway.

• Main Authors: Juliana Roberta Torini (Author), José Brandão-Neto (Author), Ricardo DeMarco (Author), Humberto D'Muniz Pereira (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosoma mansoni do not have de novo purine pathways and rely on purine salvage for their purine supply. It has been demonstrated that, unlike humans, the S. mansoni is able to produce adenine directly from adenosine, although the enzyme responsible for this activity was unknown. In the present w...