Targeting AQP9 enhanced the anti-TNF therapy response in Crohn's disease by inhibiting LPA-hippo pathway

• Main Authors: Minhao Yu (Author), Yuan Shi (Author), Yuan Gao (Author), Yang Luo (Author), Yihua Jin (Author), Xiaoyi Liang (Author), Zhuoran Tao (Author), Guojun Zhu (Author), Haiping Lin (Author), Hao Li (Author), Jun Qin (Author), Zhijun Cao (Author), Ming Zhong (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although anti-TNF antibodies are extensively used to treat Crohn's disease (CD), a significant proportion of patients, up to 40%, exhibit an inadequate response to this therapy. Our objective was to identify potential targets that could improve the effectiveness of anti-TNF therapy in CD. Throu...