The Resistance to EGFR-TKIs in Non-Small Cell Lung Cancer: From Molecular Mechanisms to Clinical Application of New Therapeutic Strategies

• मुख्य लेखकों: Carmelo Laface (लेखक), Felicia Maria Maselli (लेखक), Anna Natalizia Santoro (लेखक), Maria Laura Iaia (लेखक), Francesca Ambrogio (लेखक), Marigia Laterza (लेखक), Chiara Guarini (लेखक), Pierluigi De Santis (लेखक), Martina Perrone (लेखक), Palma Fedele (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Almost 17% of Western patients affected by non-small cell lung cancer (NSCLC) have an activating epidermal growth factor receptor (EGFR) gene mutation. Del19 and L858R are the most-common ones; they are positive predictive factors for EGFR tyrosine kinase inhibitors (TKIs). Currently, osimertinib, a...