Searching Novel Therapeutic Targets for Scleroderma: P2X7-Receptor Is Up-regulated and Promotes a Fibrogenic Phenotype in Systemic Sclerosis Fibroblasts

• Main Authors: Daniela Gentile (Author), Pietro E. Lazzerini (Author), Alessandra Gamberucci (Author), Mariarita Natale (Author), Enrico Selvi (Author), Francesca Vanni (Author), Alessandra Alì (Author), Paolo Taddeucci (Author), Silvia Del-Ry (Author), Manuela Cabiati (Author), Veronica Della-Latta (Author), David J. Abraham (Author), Maria A. Morales (Author), Rosella Fulceri (Author), Franco Laghi-Pasini (Author), Pier L. Capecchi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Systemic sclerosis (SSc) is a connective tissue disorder presenting fibrosis of the skin and internal organs, for which no effective treatments are currently available. Increasing evidence indicates that the P2X7 receptor (P2X7R), a nucleotide-gated ionotropic channel primarily involved...