Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device

• Main Authors: Robyn P Hickerson (Author), Winston C Wey (Author), David L Rimm (Author), Tycho Speaker (Author), Susie Suh (Author), Manuel A Flores (Author), Emilio Gonzalez-Gonzalez (Author), Devin Leake (Author), Christopher H Contag (Author), Roger L Kaspar (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the development of potent siRNAs that effectively target genes responsible for skin disorders, translation to the clinic has been hampered by inefficient delivery through the stratum corneum barrier and into the live cells of the epidermis. Although hypodermic needles can be used to transpor...