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Synthesis of Novel <i>N</i><sup>4</sup>-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents

Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, an ester prodrug form of <i>N</i><sup>4</sup>-hydroxycytidine (NHC), was recently e...

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Main Authors: Franck Amblard (Author), Julia C. LeCher (Author), Ramyani De (Author), Shu Ling Goh (Author), Chengwei Li (Author), Mahesh Kasthuri (Author), Nicolas Biteau (Author), Longhu Zhou (Author), Zahira Tber (Author), Jessica Downs-Bowen (Author), Keivan Zandi (Author), Raymond F. Schinazi (Author)
Format: Book
Published: MDPI AG, 2022-09-01T00:00:00Z.
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Summary:Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, an ester prodrug form of <i>N</i><sup>4</sup>-hydroxycytidine (NHC), was recently emergency-use approved for the treatment of early SARS-CoV-2 infections. Herein, we report the synthesis and evaluation of a series of novel NHC analogs.
Item Description:10.3390/ph15091144
1424-8247

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