PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia

• मुख्य लेखकों: Hsiang-i Tsai (लेखक), Yanping Wu (लेखक), Rui Huang (लेखक), Dandan Su (लेखक), Yingyi Wu (लेखक), Xiaoyan Liu (लेखक), Linglu Wang (लेखक), Zhanxue Xu (लेखक), Yuxin Pang (लेखक), Chong Sun (लेखक), Chao He (लेखक), Fan Shu (लेखक), Haitao Zhu (लेखक), Dongqing Wang (लेखक), Fang Cheng (लेखक), Laiqiang Huang (लेखक), Hongbo Chen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Mutations in the plant homeodomain-like finger protein 6 (PHF6) gene are strongly associated with acute myeloid (AML) and T-cell acute lymphoblastic leukemia (T-ALL). In this study, we demonstrated that PHF6 can bind to H3K9me3 and H3K27me1 on the nucleolar chromatin and recruit histone methyltransf...