PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia

• Main Authors: Hsiang-i Tsai (Author), Yanping Wu (Author), Rui Huang (Author), Dandan Su (Author), Yingyi Wu (Author), Xiaoyan Liu (Author), Linglu Wang (Author), Zhanxue Xu (Author), Yuxin Pang (Author), Chong Sun (Author), Chao He (Author), Fan Shu (Author), Haitao Zhu (Author), Dongqing Wang (Author), Fang Cheng (Author), Laiqiang Huang (Author), Hongbo Chen (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations in the plant homeodomain-like finger protein 6 (PHF6) gene are strongly associated with acute myeloid (AML) and T-cell acute lymphoblastic leukemia (T-ALL). In this study, we demonstrated that PHF6 can bind to H3K9me3 and H3K27me1 on the nucleolar chromatin and recruit histone methyltransf...