Multidrug resistance transporters P-gp and BCRP limit the efficacy of ATR inhibitor ceralasertib in cancer cells

• Main Authors: Xuan-Yu Chen (Author), Zhuo-Xun Wu (Author), Jing-Quan Wang (Author), Qiu-Xu Teng (Author), Hailin Tang (Author), Qianwen Liu (Author), Zhe-Sheng Chen (Author), Wenkuan Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The therapeutic effect of chemotherapy and targeted therapy are known to be limited by drug resistance. Substantial evidence has shown that ATP-binding cassette (ABC) transporters P-gp and BCRP are significant contributors to multidrug resistance (MDR) in cancer cells. In this study, we demonstrated...