Multidrug resistance transporters P-gp and BCRP limit the efficacy of ATR inhibitor ceralasertib in cancer cells

• المؤلفون الرئيسيون: Xuan-Yu Chen (مؤلف), Zhuo-Xun Wu (مؤلف), Jing-Quan Wang (مؤلف), Qiu-Xu Teng (مؤلف), Hailin Tang (مؤلف), Qianwen Liu (مؤلف), Zhe-Sheng Chen (مؤلف), Wenkuan Chen (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The therapeutic effect of chemotherapy and targeted therapy are known to be limited by drug resistance. Substantial evidence has shown that ATP-binding cassette (ABC) transporters P-gp and BCRP are significant contributors to multidrug resistance (MDR) in cancer cells. In this study, we demonstrated...