In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish

• Main Authors: Ethan Bustad (Author), Emma Mudrock (Author), Elizabeth M. Nilles (Author), Andrea Mcquate (Author), Monica Bergado (Author), Alden Gu (Author), Louie Galitan (Author), Natalie Gleason (Author), Henry C. Ou (Author), David W. Raible (Author), Rafael E. Hernandez (Author), Shuyi Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug-drug interactions that might impact ototoxicity would facilitate de...