Animal models to investigate the pathogenesis of rheumatic heart disease

• Main Authors: Catherine M Rush (Author), Brenda L Govan (Author), Suchandan eSikder (Author), Natasha L Williams (Author), Natkunam eKetheesan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatic fever (RF) and rheumatic heart disease (RHD) are sequelae of group A streptococcal (GAS) infection. Although an autoimmune process has long been considered to be responsible for the initiation of RF/RHD, it is only in the last few decades that the mechanisms involved in the pathogenesis of...