Exercise-induced irisin improves follicular dysfunction by inhibiting IRE1α-TXNIP/ROS-NLRP3 pathway in PCOS

• Main Authors: Yajing Weng (Author), Yaling Zhang (Author), Daojuan Wang (Author), Rong Wang (Author), Zou Xiang (Author), Shanmei Shen (Author), Hongwei Wang (Author), Xiaoke Wu (Author), Yanting Wen (Author), Yong Wang (Author)
• Format: Book
• Published: BMC, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Excessive production of androgen drives oxidative stress (OS) and inflammasome activation in ovarian granulosa cells (GCs). Therefore, the induced follicular developmental disorder is the major cause of infertility in women with polycystic ovary syndrome (PCOS). Exercise-induced...