Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease

• Main Authors: Stephen W. Bickler (Author), David M. Cauvi (Author), Kathleen M. Fisch (Author), James M. Prieto (Author), Alicia G. Sykes (Author), Hariharan Thangarajah (Author), David A. Lazar (Author), Romeo C. Ignacio (Author), Dale R. Gerstmann (Author), Allen F. Ryan (Author), Philip E. Bickler (Author), Antonio De Maio (Author)
• Format: Book
• Published: BMC, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Older aged adults and those with pre-existing conditions are at highest risk for severe COVID-19 associated outcomes. Methods Using a large dataset of genome-wide RNA-seq profiles derived from human dermal fibroblasts (GSE113957) we investigated whether age affects the expression...