Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients

• Main Authors: Lukas Kovar (Author), Andreas Weber (Author), Michael Zemlin (Author), Yvonne Kohl (Author), Robert Bals (Author), Bernd Meibohm (Author), Dominik Selzer (Author), Thorsten Lehr (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as conducting clinical trials in this population is especially challenging. Physiologically-based pharmacokinetic (PBPK) mode...