Population PK/PD model of tacrolimus for exploring the relationship between accumulated exposure and quantitative scores in myasthenia gravis patients

• Main Authors: Di Chen (Author), Qingyu Yao (Author), Wenjun Chen (Author), Jian Yin (Author), Shifang Hou (Author), Xiaoxin Tian (Author), Ming Zhao (Author), Hua Zhang (Author), Liping Yang (Author), Tianyan Zhou (Author), Pengfei Jin (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tacrolimus is an important immunosuppressant used in the treatment of myasthenia gravis (MG). However, the population pharmacokinetic (PK) characteristics together with the exposure‐response of tacrolimus in the treatment of MG remain largely unknown. In this study, we aimed to develop a po...