In Vivo Effects of a GHR Synthesis Inhibitor During Prolonged Treatment in Dogs

• Main Authors: Elpetra P. M. Timmermans (Author), Joëlle Blankevoort (Author), Guy C. M. Grinwis (Author), Sietske J. Mesu (Author), Ronette Gehring (Author), Patric J. D. Delhanty (Author), Peter E. M. Maas (Author), Ger J. Strous (Author), Jan A. Mol (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background:</b> The activation of the growth hormone receptor (GHR) is a major determinant of body growth. Defective GHR signaling, as seen in human Laron dwarfism, resulted in low plasma IGF-1 concentrations and limited growth, but also marked absence in the development of breast can...