Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season

• Main Authors: Johan L. Van Der Plas (Author), Pauline Verdijk (Author), Emilie M. J. Van Brummelen (Author), Rienk E. Jeeninga (Author), Meta Roestenberg (Author), Jacobus Burggraaf (Author), Ingrid M.C. Kamerling (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the main challenges in early clinical research with respiratory syncytial virus (RSV) live-attenuated vaccines (LAVs) is to assess immunogenicity in healthy adults. Healthy adults will have preexisting levels of serum neutralizing antibodies that could prematurely neutralize the LAV and under...