Developing patient-derived organoids to demonstrate JX24120 inhibits SAMe synthesis in endometrial cancer by targeting MAT2B

• Main Authors: Chunxue Zhang (Author), Xiaojing Lu (Author), Ting Ni (Author), Qi Wang (Author), Xiaoyan Gao (Author), Xiao Sun (Author), Jian Li (Author), Fei Mao (Author), Jin Hou (Author), Yudong Wang (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endometrial cancer (EC) is one of the most common gynecologic malignancies, which lacking effective drugs for intractable conditions or patients unsuitable for surgeries. Recently, the patient-derived organoids (PDOs) are found feasible for cancer research and drug discoveries. Here, we have success...