S-Ketamine Mediates Its Acute and Sustained Antidepressant-Like Activity through a 5-HT1B Receptor Dependent Mechanism in a Genetic Rat Model of Depression

• Main Authors: Kristian G. du Jardin (Author), Nico Liebenberg (Author), Manuel Cajina (Author), Heidi K. Müller (Author), Betina Elfving (Author), Connie Sanchez (Author), Gregers Wegener (Author)
• 格式: 图书
• 出版: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Rationale: The mechanisms responsible for the unique antidepressant properties of ketamine have only been partly resolved. Recent preclinical reports implicate the neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] in the antidepressant-like response of ketamine, and modulation of 5-HT1B recept...