Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells

• Main Authors: Stuart Knowling (Author), Kenneth Stapleton (Author), Anne-Marie W Turner (Author), Eugen Uhlmann (Author), Thomas Lehmann (Author), Jörg Vollmer (Author), Kevin V Morris (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small noncoding RNAs (ncRNAs) have been shown to guide epigenetic silencing complexes to target loci in human cells. When targeted to gene promoters, these small RNAs can lead to long-term stable epigenetic silencing of gene transcription. To date, small RNAs have been shown to modulate transcriptio...