Peptide-Functionalized Dendrimer Nanocarriers for Targeted Microdystrophin Gene Delivery

• Main Authors: Jessica Hersh (Author), José Manuel Condor Capcha (Author), Camila Iansen Irion (Author), Guerline Lambert (Author), Mauricio Noguera (Author), Mohit Singh (Author), Avinash Kaur (Author), Emre Dikici (Author), Joaquín J. Jiménez (Author), Lina A. Shehadeh (Author), Sylvia Daunert (Author), Sapna K. Deo (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene therapy is a good alternative for determined congenital disorders; however, there are numerous limitations for gene delivery in vivo including targeted cellular uptake, intracellular trafficking, and transport through the nuclear membrane. Here, a modified G5 polyamidoamine (G5 PAMAM) dendrimer...