Mevalonate in blood and muscle: Response to atorvastatin treatment and the relationship to statin intolerance in patients with coronary heart disease

• Main Authors: Trine Lauritzen (Author), John Munkhaugen (Author), Stein Bergan (Author), Elise Sverre (Author), Kari Peersen (Author), Sofia Lindahl (Author), Einar Husebye (Author), Nils Tore Vethe (Author)
• Format: Book
• Published: Wiley, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Statin‐associated muscle symptoms are frequently reported and often lead to discontinuation of statin therapy with an increased risk of cardiovascular events. In vitro studies suggest that statin‐mediated inhibition of the mevalonate pathway leads to muscle cell toxicity. We aimed to determ...