Loss of hepatic DEPTOR alters the metabolic transition to fasting

• Main Authors: Alexandre Caron (Author), Mathilde Mouchiroud (Author), Nicolas Gautier (Author), Sébastien M. Labbé (Author), Romain Villot (Author), Laurie Turcotte (Author), Blandine Secco (Author), Guillaume Lamoureux (Author), Michael Shum (Author), Yves Gélinas (Author), André Marette (Author), Denis Richard (Author), David M. Sabatini (Author), Mathieu Laplante (Author)
• Format: Book
• Published: Elsevier, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions into distinct protein complexes (mTORC1 and mTORC2) that regulates growth and metabolism. DEP-domain containing mTOR-interacting protein (DEPTOR) is part of these complexes and is known to reduce their...