miR-135b Stimulates Osteosarcoma Recurrence and Lung Metastasis via Notch and Wnt/β-Catenin Signaling

• Main Authors: Hua Jin (Author), Song Luo (Author), Yun Wang (Author), Chang Liu (Author), Zhenghao Piao (Author), Meng Xu (Author), Wei Guan (Author), Qing Li (Author), Hua Zou (Author), Qun-You Tan (Author), Zhen-Zhou Yang (Author), Yan Wang (Author), Dong Wang (Author), Cheng-Xiong Xu (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer stem cells (CSCs) play an important role in osteosarcoma (OS) metastasis and recurrence, and both Wnt/β-catenin and Notch signaling are essential for the development of the biological traits of CSCs. However, the mechanism that underlies the simultaneous hyperactivation of both Wnt/β-catenin...