Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration

• Main Authors: Chen Xu (Author), Shengchang Luo (Author), Leixin Wei (Author), Huiqiao Wu (Author), Wei Gu (Author), Wenchao Zhou (Author), Baifeng Sun (Author), Bo Hu (Author), Hongyu Zhou (Author), Yang Liu (Author), Huajiang Chen (Author), Xiaojian Ye (Author), Wen Yuan (Author)
• Format: Book
• Published: BMC, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Degeneration of intervertebral disc is a major cause of lower back pain and neck pain. Studies have tried to unveil the regulatory network using either transcriptomic or proteomic analysis. However, neither have fully elucidated the exact mechanism of degeneration process. Since...