Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer

Preclinical studies of PD-L1 and CTLA-4 blockade have relied heavily on mouse syngeneic tumor models with intact immune systems, which facilitate dissection of immunosuppressive mechanisms in the tumor microenvironment. Commercially developed monoclonal antibodies (mAbs) targeting human PD-L1, PD-1,...

Full description

Saved in:
Bibliographic Details
Main Authors: Darren J. Schofield (Author), Jennifer Percival-Alwyn (Author), Mateusz Rytelewski (Author), John Hood (Author), Raymond Rothstein (Author), Leslie Wetzel (Author), Kelly McGlinchey (Author), Grace Adjei (Author), Amanda Watkins (Author), LeeAnn Machiesky (Author), Weimin Chen (Author), John Andrews (Author), Maria Groves (Author), Michelle Morrow (Author), Ross A. Stewart (Author), Andrew Leinster (Author), Robert W. Wilkinson (Author), Scott A. Hammond (Author), Nadia Luheshi (Author), Claire Dobson (Author), Michael Oberst (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available