Seconeolitsine, the Novel Inhibitor of DNA Topoisomerase I, Protects against Invasive Pneumococcal Disease Caused by Fluoroquinolone-Resistant Strains

Seconeolitsine, the Novel Inhibitor of DNA Topoisomerase I, Protects against Invasive Pneumococcal Disease Caused by Fluoroquinolone-Resistant Strains

Antibiotic resistance in <i>Streptococcus pneumoniae</i> has increased worldwide, making fluoroquinolones an alternative therapeutic option. Fluoroquinolones inhibit the type II DNA topoisomerases (topoisomerase IV and gyrase). In this study we have evaluated the in vivo activity of seco...

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Main Authors: Jose Manuel Tirado-Vélez (Author), David Carreño (Author), David Sevillano (Author), Luis Alou (Author), José Yuste (Author), Adela G. de la Campa (Author)
Format: Book
Published: MDPI AG, 2021-05-01T00:00:00Z.
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