Novel Mechanism for Memantine in Attenuating Diabetic Neuropathic Pain in Mice via Downregulating the Spinal HMGB1/TRL4/NF-kB Inflammatory Axis

• Main Authors: Suliman Y. Alomar (Author), Rehab E. Abo El Gheit (Author), Eman T. Enan (Author), Khaled S. El-Bayoumi (Author), Mohamed Z. Shoaeir (Author), Amany Y. Elkazaz (Author), Sultan S. Al Thagfan (Author), Sawsan A. Zaitone (Author), Rehab M. El-Sayed (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetic neuropathic pain (DNP) is a common diabetic complication that currently lacks an efficient therapy. The aim of the current work was to uncover the anti-allodynic and neuroprotective effects of memantine in a model of mouse diabetic neuropathy and its ameliorative effect on the high-mobility...