Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine

• Main Authors: Sapna Sharma (Author), Michael A. Schmid (Author), Lorena Sanchez Felipe (Author), Jana Grenelle (Author), Suzanne J.F. Kaptein (Author), Lotte Coelmont (Author), Johan Neyts (Author), Kai Dallmeier (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plasmid-launched live-attenuated vaccines (PLLAV), also called infectious DNA (iDNA) vaccines, combine the assets of genetic immunization with the potency of replication-competent live viral vaccines. However, due to their origin as bacterial plasmid DNA, efficient delivery of PLLAV may be hampered...