Pharmacokinetic Herb-Drug Interactions of Xiang-Sha-Liu-Jun-Zi-Tang and Paclitaxel in Male Sprague Dawley Rats and Its Influence on Enzyme Kinetics in Human Liver Microsomes

• Main Authors: Alinafe Magret Kapelemera (Author), Yow-Shieng Uang (Author), Li-Hsuan Wang (Author), Tien-Yuan Wu (Author), Fang-Yu Lee (Author), Li Tai (Author), Ching-Chiung Wang (Author), Chia-Jung Lee (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paclitaxel is a prescribed anticancer drug used to treat various cancers. It is a substrate of cytochrome P-450 (CYP-450) enzymes. Despite its efficacy, paclitaxel has severe side effects. Herbal medicines are commonly used to treat the side effects of chemotherapy. They can be administered before,...