Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats

• Main Authors: Mohammed H. Elkomy (Author), Hussein M. Eid (Author), Mohammed Elmowafy (Author), Khaled Shalaby (Author), Ameeduzzafar Zafar (Author), Mohamed A. Abdelgawad (Author), Mostafa E. Rateb (Author), Mohammed R.A. Ali (Author), Izzeddin Alsalahat (Author), Heba A. Abou-Taleb (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetes mellitus is a life-threatening metabolic disease. At the moment, there is no effective treatment available to combat it. In this study, we aimed to develop berberine-loaded bilosomes (BER-BLS) to boost the oral bioavailability and therapeutic efficacy of berberine, a natural antidiabetic me...