Joint population pharmacokinetic modeling of venlafaxine and O-desmethyl venlafaxine in healthy volunteers and patients to evaluate the impact of morbidity and concomitant medication

• Main Authors: Zhanzhang Wang (Author), Lu Li (Author), Shanqing Huang (Author), Xipei Wang (Author), Shujing Liu (Author), Xiaolin Li (Author), Wan Kong (Author), Xiaojia Ni (Author), Ming Zhang (Author), Shanshan Huang (Author), Yaqian Tan (Author), Yuguan Wen (Author), Dewei Shang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Venlafaxine (VEN) is a widely used dual selective serotonin/noradrenaline reuptake inhibitor indicated for depression and anxiety. It undergoes first-pass metabolism to its active metabolite, O-desmethyl venlafaxine (ODV). The aim of the present study was to develop a joint population...