Joint population pharmacokinetic modeling of venlafaxine and O-desmethyl venlafaxine in healthy volunteers and patients to evaluate the impact of morbidity and concomitant medication

• Главные авторы: Zhanzhang Wang (Автор), Lu Li (Автор), Shanqing Huang (Автор), Xipei Wang (Автор), Shujing Liu (Автор), Xiaolin Li (Автор), Wan Kong (Автор), Xiaojia Ni (Автор), Ming Zhang (Автор), Shanshan Huang (Автор), Yaqian Tan (Автор), Yuguan Wen (Автор), Dewei Shang (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Предметы: article
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Introduction: Venlafaxine (VEN) is a widely used dual selective serotonin/noradrenaline reuptake inhibitor indicated for depression and anxiety. It undergoes first-pass metabolism to its active metabolite, O-desmethyl venlafaxine (ODV). The aim of the present study was to develop a joint population...