3D-QSAR studies on CCR2B receptor antagonists: Insight into the structural requirements of (R)-3-aminopyrrolidine series of molecules based on CoMFA/CoMSIA models

• Main Authors: Swetha Gade (Author), Shaik Mahmood (Author)
• פורמט: ספר
• יצא לאור: Wolters Kluwer Medknow Publications, 2012-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Objective: Monocyte chemo attractant protein-1 (MCP-1) is a member of the CC-chemokine family and it selectively recruits leukocytes from the circulation to the site of inflammation through binding with the chemotactic cytokine receptor 2B (CCR2B). The recruitment and activation of selected populati...