Effect of Interindividual Variability in Metabolic Clearance and Relative Bioavailability on Rifampicin Exposure in Tuberculosis Patients with and without HIV Co-Infection: Does Formulation Quality Matter?

• Główni autorzy: Glauco Henrique Balthazar Nardotto (Autor), Elin M. Svenson (Autor), Valdes Roberto Bollela (Autor), Adriana Rocha (Autor), Svetoslav Nanev Slavov (Autor), João Paulo Bianchi Ximenez (Autor), Oscar Della Pasqua (Autor), Vera Lucia Lanchote (Autor)
• Format: Książka
• Wydane: MDPI AG, 2024-07-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The present study aims to characterise the pharmacokinetics of rifampicin (RIF) in tuberculosis (TB) patients with and without HIV co-infection, considering the formation of 25-O-desacetyl-rifampicin (desRIF). It is hypothesised that the metabolite formation, HIV co-infection and drug formulation ma...