Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents

• Päätekijät: Sofya V. Lushchekina (Tekijä), Lawrence M. Schopfer (Tekijä), Bella L. Grigorenko (Tekijä), Alexander V. Nemukhin (Tekijä), Sergei D. Varfolomeev (Tekijä), Oksana Lockridge (Tekijä), Patrick Masson (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OP poisoning causes major cholinergic syndrome. Current medical counter-measures mitigate the acute effects but have limited action against OP-induced brain damage. Bioscavengers are appealing alternative thera...