Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents

• প্রধান লেখক: Sofya V. Lushchekina (লেখক), Lawrence M. Schopfer (লেখক), Bella L. Grigorenko (লেখক), Alexander V. Nemukhin (লেখক), Sergei D. Varfolomeev (লেখক), Oksana Lockridge (লেখক), Patrick Masson (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OP poisoning causes major cholinergic syndrome. Current medical counter-measures mitigate the acute effects but have limited action against OP-induced brain damage. Bioscavengers are appealing alternative thera...