Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents

• मुख्य लेखकों: Sofya V. Lushchekina (लेखक), Lawrence M. Schopfer (लेखक), Bella L. Grigorenko (लेखक), Alexander V. Nemukhin (लेखक), Sergei D. Varfolomeev (लेखक), Oksana Lockridge (लेखक), Patrick Masson (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OP poisoning causes major cholinergic syndrome. Current medical counter-measures mitigate the acute effects but have limited action against OP-induced brain damage. Bioscavengers are appealing alternative thera...