Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents

• Автори: Sofya V. Lushchekina (Автор), Lawrence M. Schopfer (Автор), Bella L. Grigorenko (Автор), Alexander V. Nemukhin (Автор), Sergei D. Varfolomeev (Автор), Oksana Lockridge (Автор), Patrick Masson (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OP poisoning causes major cholinergic syndrome. Current medical counter-measures mitigate the acute effects but have limited action against OP-induced brain damage. Bioscavengers are appealing alternative thera...