Design of Experiments (DoE)-based approach for improvement of dry mixing processes in the production of low-dose Alprazolam tablets using Raman spectroscopy for content uniformity monitoring

• Main Authors: Makraduli Liljana (Author), Makreski Petre (Author), Makraduli Filip (Author), Slaveska-Spirevska Irena (Author), Bakovska-Stoimenova Tanja (Author), Lazarevska-Todevska Elena (Author), Piponski Marjan (Author), Anevska Maja (Author), Glavas-Dodov Marija (Author), Simonoska-Crcarevska Maja (Author), Mladenovska Kristina (Author), Goracinova Katerina (Author), Geskovski Nikola (Author)
• Format: Book
• Published: Pharmaceutical Association of Serbia, Belgrade, Serbia, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A low-dose tablet formulation, containing a potent Benzodiazepine derivative Alprazolam was developed, considering the achievement of appropriate content uniformity of the active substance in powder blends and tablets as a major challenge. Two different types of lactose monohydrate (Tablettose 80 an...