Design of Experiments (DoE)-based approach for improvement of dry mixing processes in the production of low-dose Alprazolam tablets using Raman spectroscopy for content uniformity monitoring

• প্রধান লেখক: Makraduli Liljana (লেখক), Makreski Petre (লেখক), Makraduli Filip (লেখক), Slaveska-Spirevska Irena (লেখক), Bakovska-Stoimenova Tanja (লেখক), Lazarevska-Todevska Elena (লেখক), Piponski Marjan (লেখক), Anevska Maja (লেখক), Glavas-Dodov Marija (লেখক), Simonoska-Crcarevska Maja (লেখক), Mladenovska Kristina (লেখক), Goracinova Katerina (লেখক), Geskovski Nikola (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Pharmaceutical Association of Serbia, Belgrade, Serbia, 2023-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

A low-dose tablet formulation, containing a potent Benzodiazepine derivative Alprazolam was developed, considering the achievement of appropriate content uniformity of the active substance in powder blends and tablets as a major challenge. Two different types of lactose monohydrate (Tablettose 80 an...