Design of Experiments (DoE)-based approach for improvement of dry mixing processes in the production of low-dose Alprazolam tablets using Raman spectroscopy for content uniformity monitoring

• Päätekijät: Makraduli Liljana (Tekijä), Makreski Petre (Tekijä), Makraduli Filip (Tekijä), Slaveska-Spirevska Irena (Tekijä), Bakovska-Stoimenova Tanja (Tekijä), Lazarevska-Todevska Elena (Tekijä), Piponski Marjan (Tekijä), Anevska Maja (Tekijä), Glavas-Dodov Marija (Tekijä), Simonoska-Crcarevska Maja (Tekijä), Mladenovska Kristina (Tekijä), Goracinova Katerina (Tekijä), Geskovski Nikola (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Pharmaceutical Association of Serbia, Belgrade, Serbia, 2023-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

A low-dose tablet formulation, containing a potent Benzodiazepine derivative Alprazolam was developed, considering the achievement of appropriate content uniformity of the active substance in powder blends and tablets as a major challenge. Two different types of lactose monohydrate (Tablettose 80 an...