Effectiveness and mechanism of metformin in animal models of pulmonary fibrosis: A preclinical systematic review and meta-analysis

• Main Authors: Xuanyu Wu (Author), Xiang Xiao (Author), Xinyu Chen (Author), Maoyi Yang (Author), Zhipeng Hu (Author), Sijia Shuai (Author), Qinwei Fu (Author), Han Yang (Author), Quanyu Du (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Pulmonary fibrosis (PF) is a lung disease with no curative drug, characterized by a progressive decrease in lung function. Metformin (MET) is a hypoglycemic agent with the advantages of high safety and low cost and has been used in several in vivo trials to treat fibrotic diseases.Object...