Inhibition of rat locus coeruleus neurons by prostaglandin E2 EP3 receptors: pharmacological characterization ex vivo

• 主要な著者: Amaia Nazabal (著者), Aitziber Mendiguren (著者), Joseba Pineda (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Prostaglandin E2 (PGE2) is an inflammatory mediator synthesized by the brain constitutive cyclooxygenase enzyme. PGE2 binds to G protein-coupled EP1-4 receptors (EP1 to Gq, EP2,4 to Gs, and EP3 to Gi/o). EP2, EP3 and EP4 receptors are expressed in the locus coeruleus (LC), the main noradrenergic nuc...