Targeting glycolysis in non-small cell lung cancer: Promises and challenges

• Main Authors: Jia-Qi Xu (Author), Yan-Li Fu (Author), Jing Zhang (Author), Kai-Yu Zhang (Author), Jie Ma (Author), Jing-Yi Tang (Author), Zhi-Wei Zhang (Author), Zhong-Yan Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabolic disturbance, particularly of glucose metabolism, is a hallmark of tumors such as non-small cell lung cancer (NSCLC). Cancer cells tend to reprogram a majority of glucose metabolism reactions into glycolysis, even in oxygen-rich environments. Although glycolysis is not an efficient means of...