Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats

• Main Authors: Heba M. Fahmy (Author), Mostafa M. Ahmed (Author), Ayman S. Mohamed (Author), Engy Shams-Eldin (Author), Taiseer M. Abd El-Daim (Author), Amena S. El-Feky (Author), Amira B. Mustafa (Author), Mai W. Abd Alrahman (Author), Faten F. Mohammed (Author), Mohamed M. Fathy (Author)
• Format: Book
• Published: BMC, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aims The Blood-Brain Barrier (BBB) is a filter for most medications and blocks their passage into the brain. More effective drug delivery strategies are urgently needed to transport medications into the brain. This study investigated the biodistribution of thymoquinone (TQ) and the effect o...