Antileukemic potential of methylated indolequinone MAC681 through immunogenic necroptosis and PARP1 degradation

• Main Authors: Barbora Orlikova-Boyer (Author), Anne Lorant (Author), Sruthi Reddy Gajulapalli (Author), Claudia Cerella (Author), Michael Schnekenburger (Author), Jin-Young Lee (Author), Ji Yeon Paik (Author), Yejin Lee (Author), David Siegel (Author), David Ross (Author), Byung Woo Han (Author), Thi Kim Yen Nguyen (Author), Christo Christov (Author), Hyoung Jin Kang (Author), Mario Dicato (Author), Marc Diederich (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Despite advancements in chronic myeloid leukemia (CML) therapy with tyrosine kinase inhibitors (TKIs), resistance and intolerance remain significant challenges. Leukemia stem cells (LSCs) and TKI-resistant cells rely on altered mitochondrial metabolism and oxidative phosphorylati...