Antileukemic potential of methylated indolequinone MAC681 through immunogenic necroptosis and PARP1 degradation

• Главные авторы: Barbora Orlikova-Boyer (Автор), Anne Lorant (Автор), Sruthi Reddy Gajulapalli (Автор), Claudia Cerella (Автор), Michael Schnekenburger (Автор), Jin-Young Lee (Автор), Ji Yeon Paik (Автор), Yejin Lee (Автор), David Siegel (Автор), David Ross (Автор), Byung Woo Han (Автор), Thi Kim Yen Nguyen (Автор), Christo Christov (Автор), Hyoung Jin Kang (Автор), Mario Dicato (Автор), Marc Diederich (Автор)
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• Опубликовано: BMC, 2024-05-01T00:00:00Z.
• Предметы: article
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Abstract Background Despite advancements in chronic myeloid leukemia (CML) therapy with tyrosine kinase inhibitors (TKIs), resistance and intolerance remain significant challenges. Leukemia stem cells (LSCs) and TKI-resistant cells rely on altered mitochondrial metabolism and oxidative phosphorylati...