Evaluation of Pirfenidone and Nintedanib in a Human Lung Model of Fibrogenesis

• Main Authors: KM Roach (Author), E Castells (Author), K Dixon (Author), S Mason (Author), G Elliott (Author), H Marshall (Author), MA Poblocka (Author), S Macip (Author), M Richardson (Author), L Khalfaoui (Author), P Bradding (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease with a poor prognosis and increasing incidence. Pirfenidone and nintedanib are the only approved treatments for IPF but have limited efficacy and their mechanisms of action are poorly understood. Here we have exam...