Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress

• Main Authors: Winston J. T. Tan (Author), Joseph Santos-Sacchi (Author), Jane Tonello (Author), Anil Shanker (Author), Alla V. Ivanova (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2023-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Tightly regulated and robust mitochondrial activities are critical for normal hearing. Previously, we demonstrated that Fus1/Tusc2 KO mice with mitochondrial dysfunction exhibit premature hearing loss. Molecular analysis of the cochlea revealed hyperactivation of the mTOR pathway, oxidative stress,...