Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress

• Asıl Yazarlar: Winston J. T. Tan (Yazar), Joseph Santos-Sacchi (Yazar), Jane Tonello (Yazar), Anil Shanker (Yazar), Alla V. Ivanova (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2023-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Tightly regulated and robust mitochondrial activities are critical for normal hearing. Previously, we demonstrated that Fus1/Tusc2 KO mice with mitochondrial dysfunction exhibit premature hearing loss. Molecular analysis of the cochlea revealed hyperactivation of the mTOR pathway, oxidative stress,...