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Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Objective: Glucose-dependent insulinotropic polypeptide (GIP) is one of the two major incretin factors that regulate metabolic homeostasis. Genetic ablation of its receptor (GIPR) in mice confers protection against diet-induced obesity (DIO), while GIPR neutralizing antibodies produce additive weigh...

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Main Authors: Bin Yang (Author), Vasily M. Gelfanov (Author), Kimberley El (Author), Alex Chen (Author), Rebecca Rohlfs (Author), Barent DuBois (Author), Ann Maria Kruse Hansen (Author), Diego Perez-Tilve (Author), Patrick J. Knerr (Author), David D'Alessio (Author), Jonathan E. Campbell (Author), Jonathan D. Douros (Author), Brian Finan (Author)
Format: Book
Published: Elsevier, 2022-12-01T00:00:00Z.
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