DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa and Ebola viruses in guinea pigs

• Main Authors: Kathleen A. Cashman (Author), Eric R. Wilkinson (Author), Suzanne E. Wollen (Author), Joshua D. Shamblin (Author), Justine M. Zelko (Author), Jeremy J. Bearss (Author), Xiankun Zeng (Author), Kate E. Broderick (Author), Connie S. Schmaljohn (Author)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2017-12-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

We previously developed optimized DNA vaccines against both Lassa fever and Ebola hemorrhagic fever viruses and demonstrated that they were protective individually in guinea pig and nonhuman primate models. In this study, we vaccinated groups of strain 13 guinea pigs two times, four weeks apart with...