Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure

• Main Authors: Masaya Tsuda (Author), Arata Fukushima (Author), Junichi Matsumoto (Author), Shingo Takada (Author), Naoya Kakutani (Author), Hideo Nambu (Author), Katsuma Yamanashi (Author), Takaaki Furihata (Author), Takashi Yokota (Author), Koichi Okita (Author), Shintaro Kinugawa (Author), Toshihisa Anzai (Author)
• Format: Book
• Published: Wiley, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Exercise intolerance is a common clinical feature and is linked to poor prognosis in patients with heart failure (HF). Skeletal muscle dysfunction, including impaired energy metabolism in the skeletal muscle, is suspected to play a central role in this intolerance, but the underl...