Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

• Main Authors: Ashok Aspatwar (Author), Emanuela Berrino (Author), Silvia Bua (Author), Fabrizio Carta (Author), Clemente Capasso (Author), Seppo Parkkila (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Here, we report a toxicity study, conducted on zebrafish larvae, of a series of coumarin and sulfamide compounds that were previously reported as inhibitors of human (h) metalloenzymes, carbonic anhydrases (CAs, EC 4.2.1.1). Due to the high relevance of hCA inhibitors as theragnostic agents, it is o...