Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

• 主要な著者: Ashok Aspatwar (著者), Emanuela Berrino (著者), Silvia Bua (著者), Fabrizio Carta (著者), Clemente Capasso (著者), Seppo Parkkila (著者), Claudiu T. Supuran (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Here, we report a toxicity study, conducted on zebrafish larvae, of a series of coumarin and sulfamide compounds that were previously reported as inhibitors of human (h) metalloenzymes, carbonic anhydrases (CAs, EC 4.2.1.1). Due to the high relevance of hCA inhibitors as theragnostic agents, it is o...