Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

• প্রধান লেখক: Amais Ahmad (লেখক), Kayode Ogungbenro (লেখক), Annett Kunze (লেখক), Frank Jacobs (লেখক), Jan Snoeys (লেখক), Amin Rostami‐Hodjegan (লেখক), Aleksandra Galetin (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2021-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs). Pyridoxic acid (PDA) and homovanillic acid (HVA) were indicated as potential biomarkers of OAT1/3. The objective of this study...