Effect of intermittent subchronic MK‐801 administration on dopamine synthesis capacity and responsiveness in the prefrontal cortex

• Main Authors: Kazuro Shibata (Author), Kosuke Enomoto (Author), Takahiro Tsutsumi (Author), Hiroyuki Muraoka (Author), Tatsu Fuwa (Author), Masahiko Kawano (Author), Jun Ishigooka (Author), Ken Inada (Author), Katsuji Nishimura (Author), Hidehiro Oshibuchi (Author)
• Format: Book
• Published: Wiley, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aim The therapeutic potential of N‐methyl‐D‐aspartate glutamate receptor (NMDAR) antagonists, particularly ketamine, in mood disorders, is linked to their modulation of dopamine dynamics in the medial prefrontal cortex (mPFC). However, conflicting effects of distinct NMDAR antagonists, like...